Hotel Indigo Glasgow is set to open in a converted bank building in mid-2010 and will offer 96 rooms.
Hotel Indigo Liverpool is scheduled to open in spring 2011 with 151 rooms in the city centre.
IHG president EMEA Kirk Kinsell said: "Signing these two new hotels in the current climate shows we have the right strategy for growing the brand. Glasgow and Liverpool are exciting, vibrant cities and thriving tourist and business destinations that are a great match for the Hotel Indigo brand. We look forward to signing more Hotel Indigo properties in cities across Europe."
Elsewhere, the 180-room Hotel Indigo Shanghai on the Bund is set to open in China in time for the Shanghai Expo in 2010.
The launches will follow the launch of the Hotel Indigo London Paddington (pictured) last year.