As part of a year-long agreement with the BFI, The May Fair will play host to a 15-day celebration of cinema in October.
"The May Fair Hotel has become increasingly synonymous with the film and entertainment industry. It was, therefore, the obvious choice to become our official hotel," said Sandra Hebron, artistic director of the BFI Festivals.
"It will offer excellent venues for our parties, first-class suites and rooms for our VIPs, and access to one of London's largest and best equipped private cinemas."
The London Film Festival runs from 14-29 October and will bring together leading international filmmakers, industry professionals and the media together with large public audiences.