Jet will initially fly from Manchester to Mumbai on Monday, Thursday, Saturday and Sunday and will operate an A330-200, with 254 seats, on the route.
The four times a week service - with a flight time of around 10 hours - will put business and leisure passengers across Manchester Airport’s catchment area within reach of the world’s fastest-growing economy.
Secretary of State for International Trade Dr Liam Fox said: "More than a hundred Indian companies are based in the North West alone and this route will further trade relations worth £18bn between the world’s largest and oldest democracies."
Manchester Airport CEO Andrew Cowan, who said: "Securing a direct service to one of India’s major cities is the product of a lot of hard work over a long period of time to forge closer ties between Manchester and this globally significant economy."
Vinay Dube, Chief Executive Officer, Jet Airways said: "With the new flight, Jet Airways will have over 8,000 seats on offer every week, making it increasingly convenient for both business as well as leisure travelers, travelling between India and the UK, deepening commerce as well as tourism ties between the two countries."
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