The 110-room hotel, which opened in the city cetnre in 2008 during Liverpool’s Capital of Culture year, is owned by property firm Concord Estates, which is led by entrepreneur Tony Criss.
Speaking to the Liverpool Echo, Criss said: "The market is improving and the time is right to sell."
Global property consultancy, CBRE, has been given the task of finding a buyer for the property, with the asking price starting at £11m.
References to The Beatles run throughout the property, including exclusive Beatles artwork by world-renowned artists, the luxury McCartney and Lennon suites and photographs of the Fab Four dating back to the early 1960s.
The hotel also includes three meeting rooms, which can host up to 150 delegates.
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