Nods will also be made to the building's banking past with money-bag style laundry bags and a top-floor bar featuring leather satchel briefcase lights, bowler hat displays, green glass and bankers lamps.
Spread over seven floors, the reception and restaurant will be located on the sixth floor. There will also be five luxurious inner-sanctum suites complete with their own gardens.
Bosses plan to make it "one of the sexiest hotels in Europe" are hoping the property will become Manchester's second five star hotel after the Radisson Edwardian. Neighbouring Salford also has one five-star hotel, The Lowry.
Lead-designer, Oliver Redfern commented: "We wanted to pay tribute to a major building designed by ‘one of the greatest British architects’, Edwin Lutyens whilst injecting a distinct fresh personality. We hope our guests will have as much fun at Hotel Gotham as we have had in creating it".