The European-influenced lifestyle hotel will incorporate 192 bedrooms, 344sqm of meeting space and outdoor terraces with views of the Potomac River.
The eight-storey property will also feature the AC brand's signature AC Lounge serving craft beers, on-tap wines, hand crafted cocktails and a selection of small tapas-style plates.
"AC Hotels brand boasts a modern, European look and feel with Spanish roots that will complement the culturally diverse and international flavor of Washington DC," said Toni Stoeckl, vice president of Marriott's lifestyle brands.
"We believe in creating meaningful experiences for our quality-driven guests through every element of our hotel and are guided by the philosophy that everything should have a ‘why.’"
AC Hotel Washington DC at National Harbor is one of more than 50 lifestyle hotels expected to open across the US in the next few years. The brand’s first hotel debuted in New Orleans in November 2014.