The route will run from London Luton Airport to New York, Newark International Airport from 24 April. The 74-seat flights will initially operate three-times-weekly, with daily flights planned for the end of 2015.
The service is targeting the B2B sector, offering 'a unique deal that will save your company money without sacrificing the comfort of business class for your co-workers'.
La Compagnie CEO and Co-Founder Frantz Yvelin said: "It is time to bring business-class air service back to where it belongs, where personalised service is offered at respectable fares."
"Nick Barton, CEO of London Luton Airport, said: "We are delighted that La Compagnie has chosen London Luton Airport for its new business class service to New York. The announcement comes at an exciting time for London Luton with record passenger numbers achieved in 2014 and a £100m transformation programme starting in 2015."
In-flight features include lie-flat seats, gourmet food options, Caudalie cosmetic products and Samsung Galaxy tablets.
La Compagnie was launched in July 2014, operating flights from Paris to New York.