The EAIE has confirmed it will hold its annual conference at the new complex from September 12 -16 2016.
The event, which is the largest international higher education conference in Europe, will bring 5,500 delegates over five days with more expected to attend an attached exhibition. It is expected to generate £9.4m in economic benefit to the city region.
Exhibition Centre Liverpool is part ACC Liverpool, which worked closely with the University of Liverpool to secure the event, which brings together leaders and decision makers in international higher education.
Kerrin MacPhie, director of sales of ACC Liverpool, said: "We are delighted to announce this large global event which comes as a result of the relationships we have been building in the international conference market over the past four years.
"The event will use all venues within the ACC Liverpool family portfolio - BT Convention Centre, Echo Arena and Exhibition Centre Liverpool - so our entire venue will be utilised for this event. Some delegates will have the opportunity to stay in our new integrated four-star, 216-room Pullman hotel which is part of the new development.
Exhibition Centre Liverpool is expected to host about 50 events and attract more than 250,000 visitors in its first year of operation. Confirmed events so far include the Federation of Petroleum Suppliers FPS Expo, MCM Expo group and the RenewableUK conference.