American Airlines will commence the flights on Friday 8 May, arriving from JFK into Birmingham at 7.10am and departing for the return leg at 10am.
Birmingham Airport chief executive Paul Kehoe said: "This new route will not only create more capacity to this vibrant US business and tourist destination, it will also broaden connectivity and choice from the Midlands with American Airlines across North America and Canada and see the return of a British Airways flight code to Birmingham.
"Last year, the West Midlands exported £4.5bn worth of goods to North America and has the largest trade surplus with North America of any UK region, and with global brands such as JLR, JCB, Cadbury and Kraft trading both locally and in the US, this is an important link for Midlands' business."
The route is expected to provide almost 100,000 seats a year. The flights will be operated by a Boeing 757 aircraft with 22 business class seats and 160 main cabin seats.
Suzanne Boda, American Airline's senior vice-president for Asia, Canada and Europe, said: "Adding Birmingham to American's growing global network is an exciting development. Tourists from the US will have closer access to a wide range of attractions in the Midlands while business travellers will also be rewarded with greater choice when flying across the Atlantic.
"Departing passengers from Birmingham will have direct flight to New York, one of the world's most renowned business and leisure destinations, while connecting passengers will have excellent access to key business and leisure markets up and down the East Coast. We look forward to starting this new route in 2015 and I'm confident of its success."