Moxy Milan Malpensa airport is located within walking distance of Terminal 2 and has 152 rooms with ten suites.
The new brand, which Marriott announced in 2013, is being developed in partnership with Inter Hospitality, part of the Ikea group.
The Milan hotel has two meeting rooms with writing walls, large television screens for presentation projection and free wi-fi.
A Moxy hotel is planned for Heathrow airport in 2015, with further properties planned in Munich, Berlin, Frankfurt and Oslo.
Moxy Hotels expects to open 150 hotels around the world within the next ten years.