The two-day summit, organised by Road Transport Media, will take place on 25-26 November 2014 and will include delegates from Transport for London and DHL, as well as logistics operators, regulators and academics from around the world.
The aim of the conference is to discuss how out-of-hours deliveries can become a normal part of the supply chain.
Plenary sessions will take place in Twickenham’s Elgar Suite and an expo area will make use of the venue's Shakespeare Suite. A dinner will take place in the Spirit of Rugby Room.
An external expo in the West Fan Village Area immediately outside the stadium will also be used to showcase quiet vehicles and equipment.
Laura Hailstone, Quiet Cities project manager at Road Transport Media, said: "We are delighted that our first ever summit will take place at Twickenham Stadium. Its location close to Heathrow is particularly appealing for our international delegates and the range of facilities means that we can accommodate all our requirements, including an external expo. "
Samme Allen, head of conference and event sales at Twickenham Experience, added: "This is a fantastic win for Twickenham and supports our international standing as a leading conference facility for international events.
"Our ability to accommodate a large external expo, in addition to providing conference and dining facilities, has been critical in securing this opportunity and we look forward to welcoming delegates from around the world to Twickenham."