Manchester will hold the title for two years as it prepares for Europe's largest general scientific conference, ESOF – the EuroScience Open Forum – in summer 2016.
ESOF, a biennial convention dedicated to scientific research and innovation, is expected to bring 4,500 delegates to Manchester in 2016 and generate £8.3m for the local economy.
The event will take place across the city from 22-26 July 2016 and Manchester Central will act as the main ESOF hub.
Speaking at the handover ceremony held today in Copenhagen, Manchester Lord Mayor Susan Cooley said: "Manchester has a long and proud association with scientific achievement, from the work of John Dalton on atomic theory to the first programmable computer and the recent discovery of the advanced material, Graphene.
"And with Manchester presently making significant progress across numerous exciting areas of discovery, including artificial intelligence, smart textiles, and acoustics technology, there has never been a better time for the city to be recognised in this way."