The service will operate between Edinburgh Airport and Chicago O’Hare International Airport five times a week until 12 June and then daily between 13 June and 2 September.
The route will then operate four times weekly from 3 September before coming to an end on 6 October.
Nicola Sturgeon, MSP, Scotland deputy first minister and cabinet secretary for infrastructure, investment and cities, said: "This service will provide real benefits to Scotland’s economy, encouraging more tourism, trade and investment by reducing the need for travellers to make connecting flights via London or the continent."
In addition to this, the Nordic airline, Norwegian, has increased its services from London Gatwick with two new routes to Warsaw and Berlin, as well as increasing the number of departures to Copenhagen.
The airline will offer six weekly flights to Warsaw and Berlin while the Copenhagen service will grow from four to five flights daily.