Reservations can now be made for the 164-room hotel, which is located on the 47-52 floors of the 52-storey Toranomon Hills tower.
The hotel offers 770sqm of meetings space, including The Rooftop Studio, which can host 80 people for a banquet, and the Tokyo Studio for up to 220 delegates theatre-style.
Four smaller meetings studios can host from 20-50 people in a range of settings.
Arnaud de Saint-Exupery, general manager of Andaz Tokyo Toranomon Hills, said: "We look forward to offering the boutique lifestyle hotel concept to both guests and locals, which is something quite new for the Japanese hotel market."
The new hotel becomes the brand’s 12th hotel with properties in Europe, North America and the UK.