Clearwater Events USA will offer its services to destinations including Los Angeles, Las Vegas, and Phoenix and will be targeting small and medium enterprises.
The new venture will be joint-run by Stephen Morton-Prior, who will be based in the UK, and Jenifer Provence, who will be based in Phoenix, Arizona.
New partnerships will see Air Partner offer a consolidated travel package to Clearwater clients travelling to the region whilst Cvent will provide a venue finding and strategic meetings management service.
Stephen Morton-Prior, managing director at Clearwater Events, said: "This new operation will allow us to go ahead with a consolidated approach and offer 24-hour coverage to our clients.
"In the next three months we are aiming to secure three new accounts and to be an established DMC in the South Western region."
Back in the UK, Clearwater Events has seen a 40% increase in growth over the last 12 months having expanded primarily from a West Midlands-based DMC to locations throughout the country.