CTI, which was formed following the £100m acquisition of Hotelscene by TD Travel Group, has appointed office manager Matt Lambert to head up the new office.
Ian White, CTI's chief executive, said: "Hull is a city that is used to doing business – the UK's oldest Chamber of Commerce is based here. The region is home to number of multinational companies who now have a world-class travel management company on their doorstep.
"The Port of Hull is one of the UK's largest goods and passenger ports and, via CTI Marine, we can now offer our specialist fares direct to companies in the maritime industry.
"I grew up and still live in the local area and it has been a long-held desire to open an office in the centre of Hull. This city is on the brink of a renaissance and winning the UK's City of Culture 2017 will only expedite this."
CTI has an annual turnover of £100m-plus and employs 175 staff in seven locations, including London, Manchester, Bristol, Leeds, Merseyside and Bolton.