John Sharkey's departure from the SECC follows the news last week that the SECC's sales director Ben Goedegebuure is to leave in January 2014 to join Maritz Travel.
The board of Scottish Exhibition Centre Limited (SEC) is to begin the recruitment process, considering both internal and external candidates, and plans to have a replacement in place before Sharkey leaves to ensure a smooth transition.
Sharkey joined SEC as finance director in 2002 and was appointed chief executive in 2008.
Sharkey said: "I’m immensely proud of what the SEC team has achieved during my time with the business. Seeing the SSE Hydro from its gestation through construction to its successful opening was immensely satisfying. It is undoubtedly a massive privilege to have had this opportunity and now it’s time for me to take on another challenge.
"I will continue to lead the team in the coming months to help SEC consolidate the position that we have carved out for it on the worldwide stage and to help the new CEO settle in."