Ryanair, SAS and Qatar Airways will launch new routes out of airports including Stansted, Leeds Bradford and Edinburgh.
Of those announced, 12 will be flown by Ryanair from April 2014, including Stansted to Basel, Bordeaux, Brive, Bucharest, Comiso, Dortmund, Lisbon, Osijek, Podgorica, Prague, Rabat and Skelleftea.
Charlie Cornish, chief executive of Manchester Airport Group, said: "The new destinations and increase in flights on key routes will offer passengers and businesses even more choice at great value and build on the strength of Ryanair’s extensive network at Stansted."
Scandinavian airline SAS has also added seven new routes including Edinburgh to Stavanger, Edinburgh to Oslo, Aberdeen to Oslo and Leeds Bradford to Copenhagen.
Qatar Airways, as of May 2014, will launch flights from Edinburgh to Doha that will operate five times a week.