Planning permission has been granted by Glasgow City Council to build a 374-room hotel with meetings space next to Central Station in the international finance services district.
In terms of room numbers, the hotel will become one of Scotland's largest hotels, according to Sandy Smith, development director at Buccleuch Property.
Development is expected to begin in early 2014.
Motel One Edinburgh is the first property that will open, scheduled for early 2014. Motel One London is due to open at the end of 2014 and the Manchester hotel's launch date is yet to be confirmed, but is likely to be in 2015.