The General Service Board of Alcoholics Anonymous has selected the Canadian city for the International Convention of Alcoholics Anonymous between 2 and 5 July 2025.
The event, which is expected to contribute $71m (£42.4m) to the local economy, will be held at both the Vancouver Convention Centre and BC Place Stadium.
Vancouver first bid in 2003 to hold the conference and attempted once more before finally securing it this year. It beat bids for the 2025 meeting from more than 12 North American cities, including Montreal, Minneapolis and Denver.
Alcoholics Anonymous’ convention takes place once every five years and attracts delegates from more than 75 countries.
Jacqueline Benear, director of sales, meetings and conventions for the US at Tourism Vancouver, said: "Orchestrating and winning a bid of this magnitude took time and patience, and is the direct result of AA's local community approaching us in the mid-90s – they have been our steadfast inspiration ever since.
"The international convention is a cornerstone booking for our city, and a testament to the entire hospitality community’s collaboration, dedication and long-term planning. This amazing event is so powerful and uplifting to so many people, and we look forward to sharing our home with AA in 2025."