The Royal Horseguards property will be renamed as Clermont London when it reopens in 2014, following a major refurbishment.
The new upmarket brand is being launched by hotel company GLH, which runs the Thistle brand in the UK and was previously known as Guoman.
The London hotel will be followed in 2016 by two further Clermont properties based in new developments in Singapore and Kuala Lumpur, which will also both include residential apartments to be known as Clermont Residences.
Clermont Singapore will be part of the Tanjong Pagar Centre development, which will be the city’s tallest building at 290m when it opens in 2016.
Clermont Kuala Lumpur is due to open within the Damansara City development in the Malaysian capital.
Singapore-based GLH said it planned to launch 30 Clermont hotels over the next decade.
Mike DeNoma, CEO of GLH, said: "We’re delighted to launch Clermont, our new luxury hotel and private residences brand and the first hotel brand to be announced by GLH.
"Clermont is a vibrant entrant to the global luxury hotel market and we are thrilled to announce iconic new hotels and residences in a number of globally significant locations."