The event, which occurs from 4–6 June next year, is estimated to be worth £4.7m to the local economy. Its previous visits to ACC Liverpool were in 2009 and 2010.
The NHS Confederation held its annual conference and exhibition at the venue, home to BT Convention Centre and Echo Arena, in June, welcoming 2,500 delegates.
Speakers included Jeremy Hunt MP, secretary of state for health, and shadow health secretary Andy Burnham MP.
The event brings together healthcare leaders from across the NHS to discuss the evolving NHS landscape and share best practice.
Matt Tee, chief operating officer at the NHS Confederation, said: "Our decision to return to ACC Liverpool is based on past good experiences at the venue over the years. They understand our requirements which enables us to focus on the running of the event to ensure delegates enjoy a positive experience."
Kerrin MacPhie, director of sales at ACC Liverpool, said: "This year's NHS Confederation conference saw the space across BT Convention Centre and Echo Arena used to accommodate the 2,500 delegates for conference and more than 130 exhibitors. We are already working with the NHS Confederation to ensure another successful event in 2014."
ACC Liverpool recently confirmed that four medical associations will return to the venue; The National Cancer Research Institute (NCRI) conference; The British Society of Gastroenterology (BSG); the British HIV Association (BHIVA) and the British Association for Sexual Health and HIV (BASHH) and the British Society of Immunology.