The Doubletree by Hilton Dundee has 92 bedrooms and is a listed building dating back to 1870.
It is set within the grounds of a converted private family residence whose original classical period design and Latin inscriptions remain largely untouched.
The building has six acres of landscaped gardens with a maze and fountain.
Its range of meetings and events facilities include the purpose built Landmark Suite Conference Centre, with a capacity of 130 people.
For functions requiring a more intimate setting The Greystanes Suite holds up to 30 guests in what was originally a private family chapel.
Simon Vincent, president, EMEA, Hilton Worldwide, said: "Scotland remains one of the most popular destinations for our guests and Doubletree by Hilton Dundee is a great addition to our 14 strong Scottish portfolio.
"The hotel was recently named Dundee Hotel of the Year at the 2013 Scottish Hotel Awards and we are delighted to be bringing it under the Doubletreeby Hilton brand at a time when Scotland is gearing up for a huge year of tourism with its hosting of the 2014 Commonwealth Games and Ryder Cup."
The hotel is 3km from Dundee Airport and local golf courses include Downcraig, Scotsfield and Alyth. St Andrews Old Course is a short drive across the Tay Bridge.
John Greenleaf, global head, Doubletree by Hilton, said: "Our brand values hotels which portray a real sense individuality to guests whilst maintaining an upscale standard of accommodation and service.
"Doubletree by Hilton Dundee showcases the splendour of the Victorian era and provides a picturesque retreat just four miles from the city centre. We look forward to extending a warm welcome to our first guests."
Doubletree by Hilton has two further Scottish properties, with hotels operating in Dunblane, featuring Nick Nairn’s The Kailyard restaurant, and the thriving city of Aberdeen. The brand will also welcome its first hotel in Edinburgh later this year, once again in partnership with RedefineBDL.