Five Innside by Meliá hotels will be developed in Chile over the next five years and the first of these, Innside Santiago, will open in 2014 in the city's financial and commercial district.
The property will have 120 rooms and 250m2 of meetings and events space.
The second brand expansion for the group, Gran Meliá, is set to launch in Riyadh in a modern glass building in Cairo Square in the centre of the Saudi capital.
The hotel will initially provide 252 rooms, restaurants, a spa and wellness centre and a convention centre with 2,500m2 of events space. The hotel is expected to open in 2015.
Gabriel Escarrer, vice chairman and CEO of Meliá Hotels International, said: "After the success of a project such as the Gran Meliá Rome, the Gran Meliá Riyadh is another sign of our firm commitment to consolidate the brand internationally and to further enhance our presence in a market in which we began in 2011 with the opening of the Meliá Dubai.
"Saudi Arabia is a fantastic location for the luxury hotel industry, and our Gran Meliá brand will exceed the expectations of discerning, contemporary Arab business and leisure travellers thanks to its powerful service culture based around the 'Red Glove Service' – a fusion of the 'red carpet' and the 'white glove'.
"We are very excited about the prospect of operating in Chile, in particular with Innside by Meliá, a brand that is proving to be a revelation in the city hotel industry."