The 135-room Courtyard by Marriott Ulyanovsk will include a 700m2 meeting room, which will be divisible by four.
Ulyanovsk, which is 900km south-east of Moscow, is famous as the birthplace of Vladimir Lenin and today serves as a hub of industry and commerce with aerospace, automobile and mechanical engineering being the mainstay industries.
Amy McPherson, president and managing director for Marriott International in Europe, said: "The signing of the Courtyard Ulyanovsk is an exciting development as we continue to grow our footprint in Russia and expand into new areas. We continue to see great opportunity for expansion throughout Eastern Europe, particularly with our Courtyard by Marriott brand, which is specifically designed to address the needs of business travellers."
The first Courtyard by Marriott hotel built to the new European prototype is the Courtyard Aberdeen Airport, Scotland, which will open this summer.
Mariott recently announced it will open a private island resort in Venice.