The hotel is a five minute walk away from Saint Georges Hall and has 126 fully equipped rooms. It features two meeting rooms and a gym.
Thomas Dubaere, managing director of Accor UK and Ireland, said: "Accor invests in key strategically located cities. Liverpool is a fantastic city with lots on offer for business and leisure guests and the opening of this aparthotel is proof of Accor’s expansion across the UK and not just in the Capital."
Adagio Aparthotels operates 90 aparthotels in cities including Berlin, Bordeaux, Brussels, Geneva, Marseille, Monaco, Munich, Paris, Rome, Strasbourg and Vienna.
By 2016 a further 60 aparthotels will open worldwide.