Executives from the programme’s production company, Fremantle Media, and Talk Talk, which sponsors the show, are expected to attend the show’s climax and after-show celebratons.
The events venue, which completed a £30m redevelopment this year, will host the music show’s final. Angie Robinson, Its chief executive, said: "This is the first X Factor final to be held outside of London and I am delighted that Manchester Central has been chosen for it.
"We are thrilled to welcome The X Factor to Manchester. We have a track record of delivering the best events, conferences and meetings in the UK.
"The nation will be firmly focussed on Manchester Central this weekend and we are ready for it."
Corporates expected to be in attendance include representatives from Fremantle Media and Talk Talk, whose customer marketing campaign promised to deliver 10,000 tickets across the final weekend, representing half of the total audience.