Claire Joffe, Director of Projects and current co-owner, will also be leaving the company on 31 December 2012.
Michael and Claire will be remaining in consultative roles until 1 March 2013 to ensure the smooth transition to new management.
Dion Bassett will remain with Kenes UK as Senior Project Manager.
Inbar Caspi, currently Senior Project Manager of Kenes International, has been appointed to oversee operations in London.
Inbar has worked with Kenes for seven years and has led the management of key congress projects for Kenes.
Dan Rivlin, CEO of the Kenes Group said: "We are grateful to Michael and Claire for helping Kenes cement a foundation in the UK market and their efforts in building the company over the past three years.
"We wish them every success in their future endevours. Inbar is a true professional and we are sure that under her leadership, as well as with continued support from the Kenes Group, we will continue to achieve our vision and grow our presence in the UK with renewed energy and focus."
Michael Foreman stated: "I am extremely proud of what we have achieved at Kenes UK in a very short time. In less than three years we have made very impressive and significant inroads into the medical association congress market and achieved our strategic vision of becoming a leader in this niche field.
"Having achieved my personal goals for the company, I have decided to seek out new challenges. I wish Kenes UK and the Group every success in the future."
Michael will remain in post as chairman of the Association of British Professional Conference Organisers.