The IHG-managed hotel will be located in midtown Manhattan in East 44th Street and is scheduled to open in late 2014.
The 230-room hotel will include dedicated meeting areas, as well as indoor and outdoor exercise spaces, as part of its focus on health and wellness.
IHG expects to sign 100 Even Hotels in the US in the next five years under managed and franchised agreements in key markets including New York, Washington DC and San Francisco.
The group’s chief executive Richard Solomons said: "This is another important first for IHG. By developing our portfolio of preferred brands in line with emerging consumer preferences, we are meeting the needs of a new type of guest who’s looking for hotels with an intrinsic focus on wellness in terms of food, work, exercise and rest."