The £87.4m Hilton Columbus Downtown hotel has a total of 2,880sqm of meetings and events space, connected by a pedestrian skybridge to the Greater Columbus Convention Center.
Hilton Hotels and Resorts global head Dave Horton said: "This area is a growing centre of tourism and events in Central Ohio. The opening of Hilton Columbus Downtown is an important and exciting addition to the Hilton family of properties."
Event spaces across the hotels first and second floors include the George Bellows Ballroom for up to 1,320 delegates theatre-style, as well as private dining space and a boardroom.
The hotel is designed to attain certification from the US Green Building Council, while its restaurant aims to source local ingredients.
Tourism body Experience Columbus’ vice president of sales Brian Ross said: "The new, full-service convention hotel significantly enhances our convention package and allows Columbus to compete for a larger share of the state, regional and national convention, meeting and tradeshow market and sporting events."