More than 3,300 attendees from over 70 countries are expected to attend ISPOR's event from 2 to 6 November 2013.
ESCAP's bi-annual four-day event is expected to attract more than 2,000 delegates.
Dr Marilyn Dix Smith, Executive Director at ISPOR said: "ISPOR held our 10th European Congress in Dublin in 2007 and experienced a nearly 30 per cent growth in attendance. Dublin was a popular and attractive destination for our attendees.
"The CCD enables us to return to Dublin in space large enough to accommodate the growth in our programme and in our attendance. The 2013 Congress will bring people together, in the beautiful setting of Dublin, to debate the difficult but essential question of how we best use health care resources."
The Congress will feature educational courses, plenary sessions, issue panels, workshops, research poster and podium sessions, symposia and exhibits.
Marie Lawlor, Head of Conference Sales at The CCD said: "We are delighted to be hosting ISPOR in 2013 for its’ second visit to Ireland in eight years. It shows that Dublin is an extremely popular destination with delegates and societies.