The Clubhouse at 11-14 Grafton Street has four meeting rooms for up to eight people, a boardroom seating up to 12 delegates and a presentation room for up to 30 people.
The Clubhouse chief executive and founder Blaskey said: "The Clubhouse has been borne out of a need I have had over the past ten years having had a number of meetings, like many other people, in hotel lobbies and coffee shops across London.
"Our target market is the growing number of people leaving larger firms and setting up their own businesses."
Paragon Events has been appointed as the events management provider at the venue and director of events Frances Barnes said: "It is a great location in the heart of Mayfair and will work really well for events like product launches and fashion shows."
Blaskey is planning to launch further sites in 2013.