The International Paralympic Committee (IPC) and the British Paralympic Association (BPA) will host the fundraising evening which will include appearances from Paralympic medal winners.
Live entertainment, including action from the Paralympic Games, an auction, drinks reception, four course dinner and After Party will occur.
Amongst the 750 expected attendees will be IPC President Sir Philip Craven, BPA President Tim Reddish together with celebrities from the world of sport and showbiz.
Tim Hollingsworth, chief executive of the British Paralympic Association, said: "The Paralympic Ball will be a fantastic opportunity for us to celebrate the Paralympic Games and there can surely be no better time to hold it than during London 2012, which looks set to be the biggest and best Paralympics yet. It will undoubtedly be a great event and I am delighted that the BPA can support it in partnership with the IPC."
Nathan Homer, Paralympics director P&G UK and Ireland added: "P&G is delighted to be an official partner of the Paralympic Ball to celebrate the power of the Paralympic Games. The ambition, talent and sheer determination of the ParalympicsGB athletes is truly inspirational. In addition to honouring these world-class athletes, we’re also using our voice to recognise their nearest and dearest - like their mums - who have supported them in achieving their dreams."