LLDC said it is looking to recruit a replacement for incumbent Andrew Altman, who has been in the role for three years.
Altman will leave the organisation on 15 August, at which point Dennis Hone, chief executive of the Olympic Delivery Authority, will fill the vacancy on an interim basis.
LLDC credits Altman with playing a key role in transofmring the 500 acre Queen Elizabeth Olympic Park into a "new international centre of economic growth that will create a thriving new community, accommodating over 7,000 new homes [and] creating thousands of new jobs".
Altman said: "I am proud to have been able to set the table with a clear vision, resources and commercial investment. It is now the perfect time to transition the project to one focused on construction, so there will no disruption after the Games in implementing the legacy vision we have crafted.
"I especially want to thank Mayor Boris Johnson for his support and leadership without which this could not have been achieved."