The financial services giant, which is one of the sponsors of the Olympics, has hired the majority of the four-star hotel's event spaces, with first option to book events and meetings throughout the Games for up to 3,000 delegates.
Meanwhile, the Hilton Metropole London, which renovated all its meeting room and event spaces earlier this year, is poised to refurbish and expand its lobby in size by 45% after the Games.
The hotel's general manager, Avner On, said that, as well as the ongoing multi-million pound redevelopment of the property, his focus has been on staff retention.
"Looking after staff has been my priority," he said, "and I've managed to cut staff turnover by 80% since I joined in 2003. We have also seen vastly improved feedback from staff."
Visa works with event agencies including Bluehat UK and has previously hired venues including Forman's Fish Island, which is located near the Olympic Stadium. The brand, which is running an Olympic advertising campaign entitled Go World, is using the Games as a chance to promote its mobile phone payment system, Paywave.