The event is set to attract 550 delegates and will be held at the ICC Birmingham in September.
Designed to be motivational, the programme will also include a celebration lunch.
Cascade, whose clients also include Iceland, also organised Poundland's 2011 conference, which took place at the Telford International Centre's new Ludlow Suite.
"Poundland has been a valued client for six years and has grown considerably in that time," said Cascade Productions managing director Alan Wight. "We only do two events a year for them, but produce a number of training DVDs each year."