Johnson announced that, as part of the capital's Olympic drive, more than 100 global business leaders will take part in his ‘London House’ initiative.
The programme will see City Hall transformed into a hub for businesses to take part in debates, seminars and networking with representatives from UK leaders in the technology, creative, environmental and financial services sectors.
Microsoft, LG, Tata Consultancy, Shanghai Pudong Development Bank, Time Warner, Paramount Pictures, Banco Itau, Tsingtao Brewery and Iberdrola Engineering and Construction are among the confirmed brands.
Johnson said: "We have a fantastic summer ahead but I have always said that if the Games are to mean anything we must use them as a springboard from which we can transform this city for generations to come. We’re already seeing a renaissance in east London and billions of pounds worth of investment that would never have been secured had it not been for the Games.
"We have to capitalise on this positive momentum and as mayor I will do all I can to help secure the Olympic legacy that has always been promised. By driving investment and helping to deliver thousands of new jobs, homes and infrastructure, we can make London an even better place to live and work, long after the Games have gone."