The event, which is forecast to attract 7,000 delegates, will take place at the Scottish Exhibition & Conference Centre (SECC) in September. It marks the first time in over a decade that the political party has chosen Scotland to host its conference.
Liberal Democrats leader and deputy prime minister Nick Clegg said: "I’m delighted that we are taking our Autumn Conference to Glasgow, particularly at such an important time in Scotland’s and the UK’s history.
"Our party has always led the way in campaigning for devolution, and I hope coming to Glasgow will remind Scots that we are committed to continuing that process and securing their future as part of the UK."
Ben Goedegebuure, the SECC’s director of sales, added: "Glasgow is fast becoming a natural choice for large meetings and forums and we're delighted to be welcoming such a high-profile event.
"Political forums are superb for venues like ours to host. They are dynamic, versatile and will use every part of the SECC's spaces and services, which means they get the most out of their event both in the venue and in the destination."