The group, which will include KFC and Pizza Hut managers, will enjoy a visit to Table Mountain and the Cape of Good Hope, as well as a yacht trip.
KFC events planner Leigh Acutt said: "We chose Cape Town as you cannot beat it for value for money. The itinerary is full on. The reaction from the delegates has been amazing. The flight is overnight and with a one-hour time difference we won't suffer from jetlag."
DMC Green Route has been appointed help organise the trip for Yum Restaurants, and the group will fly with South African Airways.