Bids to further use the venue for a "full array of sporting, cultural and commercial events" are due by March 2012. The OPLC plans to appoint the winning bidders in May, ahead of plans to reopen the venue in 2014.
The stadium will be retained by the Legacy Company as a public asset, to be operated as part of a joint venture with the London Borough of Newham.
Newham has offered to invest up to £40m towards transforming the stadium in order to secure legacy benefits for the borough.
OPLC chief executive Andrew Altman said: "Having already secured the 2017 World Athletics Championships, now is the time for bidders to come forward to further enhance the stadium’s legacy."
Mayor of London Boris Johnson, said: "We are already securing a lasting legacy for London, with our fantastic Olympic Stadium set to become not only one of the world’s premier destinations for sports, but also a first class hub for culture and entertainment. Opening up the bidding to other interested parties now shows just how far ahead we are in planning a great future for east London long after the Games have left town."