The hotel, scheduled to open in 2014, is expected to be the sixth Mondrian hotel in the group and the first Mondrian hotel located in Europe.
The 360-room property is expected to feature an innovative restaurant and both a ground floor and rooftop bar, specially conceived by The Light Group.
Morgans Hotel Group CEO Michael Gross commented: "We are very excited to announce our first Mondrian hotel in Europe. Sea Containers is an exceptional property in a key gateway city"
Earlier in the year, the group also announced further Mondrian-branded hotels in Doha, Qatar and in Nassau, The Bahamas.