Derbyshire joins the firm from advertising agency JWT Manchester, where she was senior account director of its John West Foods account.
Her appointment is central to The Tailor of Shoreditch's strategy to offer clients more integrated marketing services.
Tailor of Shoreditch founder Ian Irving said: "People may be more familiar with my experience within the experiential and events industry, but our recent work goes beyond that.
"We take a collaborative approach so we can bring in experts from whichever disciplines will have the most impact for that particular client. Laura’s appointment further strengthens our integrated approach."
Prior to working at JWT, Derbyshire held posts at below-the-line marketing agencies Proximity London, Haygarth, Sledge and Iris.
She said: "Client demand has shifted to an integrated approach. Only an agency that is truly media neutral can first focus on a client’s business challenges and then choose the most appropriate channels.
"As customer centricity is becoming more important marketers should be looking outside their current expectations and set themselves free from traditional blinkered thinking."