Themed Making Business Easy, the two-day conference and networking event will take place at De Vere Wychwood Park hotel in Cheshire on 8-9 September.
The conference is targeting a total of 690 delegates and Synaxon will also be presenting its first UK Supplier and Partner Awards at the event.
Key members of Synaxon's executive board from Germany will make presentations via pre-recorded video.
There will also be presentations from headline sponsors of the event, Acer and Fujitsu.
Synaxon UK managing director Derek Jones: "The first Synaxon UK conference will be unmissable. It’s important to work hard and be professional, but you also need to develop good relationships with the people you deal with and to enjoy what you do. We're aiming to do both at the conference."
The conference follows two debut regional events held at De Vere Daresbury Park, Warrington, on 22 March and De Vere Wokefield Park, Reading on 16 June.