The Hilton Frankfurt Airport and Hilton Garden Inn Frankfurt Airport will open in December at The Squaire development.
Hilton Frankfurt Airport will have 249 rooms and a pillarless ballroom with a Swarovski crystal ceiling for up to 570 for a cocktail reception and 540 for a conference.
An elevator to the fifth floor where the event space is located can accommodate a car for automotive launches.
A further ten function rooms can accommodate up to a total of 400 delegates.
Hilton’s cluster director of business development for the new hotels Marc Snijders said: "The nice thing about The Squaire is its accessibility. There is a walkway to Frankfurt Airport terminal one and it is at the junction of two major roads."
He added the hotels had already signed contracts to hold 50 events each year in 2012 and 2013.
Hilton Garden Inn Frankfurt Airport will have 334 rooms and three meeting rooms.
The Squaire development has been built on 86 steel pillars above the region's high-speed rail station and also features shops and office space.