The 120-room Doubletree by Hilton Bratislava opens in summer 2011 and will be located 2.5km from the city centre in the commercial district of the capital city.
Conference facilities include a 500sqm ballroom and eight additional meeting rooms, ranging from 52sqm to 150sqm.
It also features a restaurant, bistro bar, spa with swimming pool and sauna, and a fitness centre all feature.
Hilton Worldwide senior vice president of development Patrick Fitzgibbon said: "Our growing presence in Slovakia demonstrates the increasing demand by investors and guests for the Hilton Worldwide portfolio of brands, particularly in Eastern Europe and in capital city locations."
Doubletree by Hilton Bratislava will join Doubletree by Hilton Kosice, which has been operating in Slovakia since early 2009.