Fisher Scientific, a laboratory products supplier, and property investment company Harlequin Property are among businesses that booked events in 2010.
The London 2012 Olympics team also held an event at Wembley Stadium this year, along with NLP Training and the Sports Merchandise Exhibition (Smex).
Wembley Stadium’s hospitality provider is Delaware North Companies and head of sales, conference and banqueting Jackie Boughton said: "After the turmoil of 2009 it has been fantastic to see our clients rallying to the benefits of events. They have embraced the overwhelming power of face to face meetings and used them to improve their businesses."
She added that the sales team had "worked tirelessly" to forge new contacts and win business.