The event will be held at the Southport Theatre & Convention Centre from 5-7 November 2010.
It will attract about 400 delegates to the resort and feature policy discussions, a series of keynote speeches from attending Shadow Cabinet Ministers in addition to an exhibition, conference dinner and reception.
Louise Baldock, chair of Labour North West's Regional Board, said: "We're delighted to be returning to Southport for the fourth consecutive year. The regional conference will generate thousands of pounds for the local economy with hundreds of visitors including delegates and exhibitors coming to Southport."
Tony Corfield, Assistant Director of Leisure & Tourism Sefton Council added: "Major political events such as this not only bring a significant contribution to the area's economy through delegate spend, but also play a crucial role in helping to highlight Southport's strength and credibility as a destination for conducting business."