The travel trade show, which runs from 8-11 May, will feature nearly 2,000 exhibitors including Durban's stand, a scaled down version of the iconic Moses Mabhida stadium.
Highlights of this year's show will include the launch of Durban's new tourism trail in the Inanda region, where Mahatma Gandhi lived and developed his ideas of passive resistance.
"We want to make sure that Durban gets the maximum share of the visitors headed to South Africa for the upcoming World Cup," said acting Durban Tourism head Philip Sithole.
"We are in a bid process with the province to host Indaba for the next three years," he added. "We have hosted this event very successfully for two decades and we really believe that Durban should be made the permanent home for Indaba."
Visit C&IT's South Africa destination guide here
Click here to see photos of South Africa's Fifa 2010 World Cup teams' base camp hotels
See photos of South Africa's 10 Fifa 2010 World Cup stadia here
Read Dragonfly sales and marketing manager Robin Mcleod's blog on Cape Town as part of his insider's countdown to the South Africa World Cup.