The hotel, currently operating as the Holiday Inn Amsterdam Schiphol, opened in 2007 and offers 342 rooms and more than 1,800sqm of events space.
The venue's 19 meeting rooms have floor-to-ceiling windows and capacity for 1,700 delegates.
Facilities also include Brasserie Leeghwater, the Grand Café and the Waterwolf Bar & Lounge.
Park Plaza Hotels president and chief executive Boris Ivesha said: "We are absolutely delighted that we have been able to acquire such an impressive conference hotel. This will be our third hotel in the Amsterdam area with a fourth under development and really strengthens our position in the important Dutch market."