The airline will run two flights a week to both Boston and Los Angeles from Manchester.
It has also announced plans to increase the frequency of its existing US routes. It will increase its Manchester to New York and Las Vegas routes to six flights a week in 2016, while its service to Orlando will become a daily service during the peak season in summer 2016.
Christoph Debus, chief airlines and hotels officer for Thomas Cook Group, said: "We are incredibly proud to have the largest non-stop route network from Manchester Airport, with 15 long-haul destinations including six to the USA - more long-haul routes than any other carrier from Manchester. With Manchester as a hub for our airlines across Europe as a gateway to the US, today's announcement of new routes to Los Angeles and Boston is great news for our customers with even more choice from outside London."
Ken O'Toole, managing director of Manchester Airport, said: "The announcement of services to Los Angeles and Boston, which makes Manchester the only airport outside of London to offer them, complements Thomas Cook's recent launches of New York and Miami. With over 22 million people living within our two-hour catchment, two full-length runways and all-time record passenger numbers, Manchester Airport is, and will continue to have, the available capacity and demand to meet the needs of our catchment that extends as far north as Scotland and south to the Midlands."
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